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研究所实验室
神经发育疾病实验室
信息来源:暂无    发布日期:2016-10-20   浏览次数:  

徐丹博士

2007年西北大学学士, 2010年西北大学硕士,2015年中国科学院遗传与发育生物学研究所博士。2015年福州大学生命科学研究所助理研究员。

主要研究方向

主要从事神经发育疾病及其病理机制的研究。常染色体隐性遗传小头畸形是一种神经系统发育障碍疾病,主要表现为是头围减小并伴随一定程度的智力衰退。该实验室主要利用子宫内胚胎电转技术(IUE)及基因敲除小鼠模型研究小头畸形症的分子细胞学机制。

子宫内胚胎电转技术目前被广泛应用于神经发育的相关研究。以孕鼠为材料,将质粒DNA(过表达或敲降质粒)电转到胎鼠大脑皮层干细胞区,研究转染细胞的增殖、分化和迁移过程。

同时通过分析基因敲除小鼠的生长发育过程及行为学特征来进一步研究神经发育疾病的病理机制。

发表论文:

1. Li, C. #, Xu, D. #,Ye, Q., Hong, S., Jiang Y.S., Liu, X.Y., Zhang, N.N., Shi, L., Qin, C.F., Xu, Z.H. (2016). Zika Virus Disrupts Neural Progenitor Development and Leads to Microcephaly in Mice. Cell Stem Cell 2016, 19, 120-126.( #co-first)

2. Zhang, F., Yu, J., Yang, T., Xu, D., Chi, Z., Xia, Y., and Xu, Z. (2016). A Novel c-Jun N-terminal Kinase (JNK) Signaling Complex Involved in Neuronal Migration during Brain Development. J Bio Chem. 291, 11466-11475.

3. Xu, D., and Xu, Z. (2016). Driving WDR62 to the pole. Cell cycle 15, 1180-1181.

4. Xu, D., Zhang, F., Wang, Y.Q., Sun, Y.M., and Xu, Z.H. (2014). Microcephaly-associated protein WDR62 regulates neurogenesis through JNK1 in the developing neocortex. Cell Rep. 6, 104-116.

5. Zhang, F., Xu, D., Yuan L., Sun, Y.M., and Xu, Z.H. (2014). Epigenetic regulation of Atrophin1 by lysine-specific demethylase 1 is required for cortical progenitor maintenance. Nat Commun 5, 5815.

6. Lim, N.R., Yeap, Y.Y., Zhao, T.T., Yip, Y.Y., Wong, S.C., Xu, D., Ang, C.S., Williamson, N.A., Xu, Z., Bogoyevitch, M.A., et al. (2014). Opposing roles for JNK and Aurora A in regulating WD40-Repeat Protein 62 association with spindle microtubules. J Cell Sci.

7. Du, Z.#, Xu, D. #, Li, L., Shi, Y., Schlappi, M., and Xu, Z.Q. (2012). Inhibitory effects of Arabidopsis EARLI1 against Botrytis cinerea and Bradysia difformis. Plant Cell Tiss. Org. 110, 435-443. (#co-first)

8. Li, L., Zhang, C., Xu, D., Schlappi, M., and Xu, Z.Q. (2012). Expression of recombinant EARLI1, a hybrid proline-rich protein of Arabidopsis, in Escherichia coli and its inhibition effect to the growth of fungal pathogens and Saccharomyces cerevisiae. Gene 506, 50-61.

9. Xu, D., Huang, X., Xu, Z.Q., and Schlappi, M. (2011). The HyPRP gene EARLI1 has an auxiliary role for germinability and early seedling development under low temperature and salt stress conditions in Arabidopsis thaliana. Planta 234, 565-577.

10. Xu, Z.Q., Huang, X.A., Feng, C., Tian, N., Xu, D., and Feng, S.Z. (2010). Multicellular genesis of leaf primordium was demonstrated via chimaeric transgenic plant of maize (Zea mays L.) regenerated from Type II calli. Mol. Biol. Rep. 37, 3525-3531.

11. Chen, L.Y., Chen, Q.L., Xu, D., Hao, J.G., Schlappi, M., and Xu, Z.Q. (2009). Changes of gentiopicroside synthesis during somatic embryogenesis in Gentiana macrophylla. Planta Med. 75, 1618-1624.

12. Xu, D., Chen, L.Y, Xu, Z.Q. (2009). In vitro regeneration and histological observation in sweet sorghum. Plant Physiol. Commun. 45, 771-774

 

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